AMPLIFIED Formula Profile

 

 

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Citrulline Malate 3:1

Citrulline malate is the amino acid L-Citrulline bound with Malic Acid. L-Citrulline is converted in the kidneys into L-Arginine, which has long been used in the supplement industry as a substrate for production of Nitric Oxide. However, the body much better absorbs Citrulline than Arginine. In fact, Citrulline is shown to increase plasma Arginine levels even more effectively than Arginine itself! Yes, studies show that supplementing with Citrulline will raise Arginine to a greater degree, and for a longer duration, than simply taking an equal dose of Arginine. The Malic Acid component also contributes to cellular energy production. In summary, according to the latest sports science, Citrulline Malate has been shown to provide the body with:
Greater Nitric Oxide Production – for more intense, longer-lasting pumps and vascularity.
Reduced Lactic Acid and Ammonia buildup during exercise – to help you train harder and longer.
Amplified Cellular Energy (ATP) Production – to help your muscles power through intense activity.
- Note: not all Citrulline Malate blends are created equal: Look across the pre-workout category and you will see cheaper forms of Citrulline Malate at ratios of 1:2, 1:1, and at most a 2:1 ratio of Citrulline to Malic Acid. Amplified uses an extremely potent 3:1 ratio of Citrulline-to-Malate for maximum effect.
The clinically effective dose of Citrulline Malate to enhance sports performance is shown to be around 6,000 – 8,000 mg (6g-8g), taken before exercise.
Citrulline Malate Research Links:
Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins. (1997)
Citrulline malate promotes aerobic energy production in human exercising muscle. (2002)
L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. (2006)
Citrulline and the gut. (2007)
Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. (2008)
Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. (2010)
L-citrulline-malate influence over branched chain amino acid utilization during exercise. (2010)
Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle. (2011)
Effects of citrulline supplementation on fatigue and exercise performance in mice. (2011)
Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. (2012)

 

Beta-Alanine (CarnoSyn®)

Beta-alanine, also known by its trademarked name CarnoSyn®, is the building block of carnosine, a molecule that helps to buffer acid in muscles, increasing performance in prolonged, intense physical activity.
Beta-alanine, by elevating muscle carnosine levels, enhances the performance capabilities of muscle in 4 ways:
Extended Endurance
Faster Muscle Recovery
Greater Muscle Strength
Enhanced peak performance capabilities
When shopping beta-alanine supplements, always look for the trademark name CarnoSyn®. CarnoSyn® is owned by Natural Alternatives International, Inc. who the patent holder on the manufacturing process by which beta-alanine is made, and is the only beta-alanine source that has been proven effective by repeated, reputable research.
Studies on beta-alanine have indicated a minimum effective dosage of 3.2 grams per day for at least four weeks. Beta-alanine can provide a notable stimulant effect and is typically taken as a pre-workout supplement. Large doses of beta-alanine may cause a tingling feeling called paresthesia. It is a harmless side effect. Some people report enjoying the sensation because it helps them feel the supplement working
- Note on Taurine:
Taurine and beta-alanine share the same transporter (SLC6a6), so competition for absorption may occur. ** We chose to separate the dosage of beta alanine from Taurine to maximize both nutrients’ absorption in the body. A full dose of Beta-Alanine is in AMPLIFY, while Taurine is included in INFUSED.
Beta-Alanine Research Links: 
CarnoSyn® Research Site Containing 55 Scientific Studies: http://www.carnosyn.com/research
Suzuki, Yasuhiro, et al. "High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting." The Japanese journal of physiology 52.2
Kern BD, Robinson TL. "Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance: A Review of the Current Literature". J Strength Cond Res. (2011)

 

Creatine MagnaPower®

Creatine MagnaPower®, or magnesium creatine chelate, is a patented version of creatine molecularly bonded to magnesium to promote the synthesis and regeneration of ATP (Adenosine Triphosphate - your primary “energy currency” within the cell). This unique form of creatine is shown to have far superior absorption and bioavailability over other forms of creatine.
Creatine  is a well-known, well-researched sport supplement that gained widespread popularity in the early 1990s. Creatine directly aids in the replenishment of ATP (ATP = Andenosine Triphosphate - your primary “energy currency” within the cell). Numerous studies have shown that creatine can increase muscular strength and size, as well as reduce recovery time. It’s been used by athletes for decades to increase high-intensity exercise capacity and lean body mass. More recent research also suggests that creatine can improve neural function and reduce perceived mental fatigue.
Magnesium is needed for over 300 biochemical reactions in the body and helps maintain normal muscle and nerve function. Magnesium also helps regulate blood sugar levels, promotes normal blood pressure, and is known to be involved in energy metabolism and protein synthesis.
Creatine is sold in a variety of forms, including creatine monohydrate, creatine ethyl ester, creatine alpha-ketoglutarate, tri-creatine malate, creatine citrate, magnesium creatine chelate. Though all types of creatine are sold for the same purposes, there are differences between them, such as price, necessary dosage, effectiveness, utilization, and bioavailability.
We chose Magnesium Creatine Chelate for our formula because it brought these unique benefits to the table:
Minimal reliance on insulin (carbohydrate) spikes to facilitate absorption. This is important for those on low-carb or no-carb diets.
No Loading Phase
No bloating or stomach discomfort
Minimal extracellular water retention (no“puffy” look)
ZERO Conversion to creatinine, an inactive waste product, so you actually use the creatine you ingest.
Creates a higher level of absorption and utilization than creatine monohydrate.
 Numerous studies have shown it can increase muscular strength and size, as well as reduce recovery time.
Creatine MagnaPower® Research Site Containing 7 Scientific Studies and Video Breakdown: http://creatinemagnapower.com

 

Betaine Anhydrous

Betaine (pronounced "BEE-tane") Anhydrous, aka Trimethylglycine, has been shown to increase muscular endurance, strength, and growth hormone production in response to exercise. 
In a study done at the University of Connecticut, the UCONN researchers found that resistance-trained athletes (experienced weight-lifters) increased their muscle strength by 25 percent, and their muscle power by 20 percent, by taking 1.25 grams of betaine twice per day.
We utilize this same proven nutrient timing in our first two products – The first 1.25g dose is found in AMPLIFY, the second is included in INFUSED, our intra-workout FORMULA designed to complement the effects of AMPLIFY. Taking AMPLIFY pre-workout and INFUSED during your workout is our recommended way to utilize this exact nutrient timing.
(Anhydrous simply means that all water has been removed to create a powdered form.)
Betaine Research Links:
Effect of betaine supplementation on power performance and fatigue. (2009)
Ergogenic effects of betaine supplementation on strength and power performance. (2010)
The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance-trained men. (2011)
Effect of betaine supplementation on cycling sprint performance. (2012)
Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise. (2013)

 

L-Tyrosine

L-Tyrosine is an amino acid that is known to increase mental focus, boost energy, improve mood, and even assist in fat metabolism. Inside the body, Tyrosine is used to produce vital hormones and neurotransmitters, such as thyroid hormones, dopamine, norepinephrine, and also epinephrine. Research shows that elevated epinephrine levels may reduce fatigue. A study done with military cadets showed that ingesting tyrosine improved mental and physical performance, while reducing fatigue during demanding military combat training drills.
L-Tyrosine tends to be taken in doses of 500-2000mg approximately 30-60 minutes before any acute stressor (such as exercise) 
Tyrosine Research Links:
Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. (1989)
Tyrosine reverses a cold-induced working memory deficit in humans. (1994)
The effects of tyrosine on cognitive performance during extended wakefulness. (1995)
Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. (1999)
Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. (2007)

 

Choline Bitartrate

 Choline Bitartrate is a stable form of choline that can, in acute doses, not only provide cognitive benefits but provide increased muscle endurance and reduced fatigue. For pre-workout supplementation, choline should be pulsed in high doses acutely as higher doses are partitioned to the brain to a greater extent. 1g-2g is typically used.
Excess choline is actually converted into another powerful nutrient – One that is also profiled here: trimethylglycine (Betaine).
Choline Research Links:
Effects of Choline on Athletic Performance & Fatigue. (1996)
Choline and betaine in health and disease. (2011)

 

Caffeine Anhydrous

Caffeine is a popular, powerful stimulant that is proven to be able to increase muscle endurance, strength and exercise performance. Caffeine works primarily by increasing Noradrenaline, the neurotransmitter in the brain most responsible for concentration. Research shows optimally effective dosages vary between 4mg and 6 mg per kg of bodyweight. (For a 180lb person, this equals 326mg-490mg of caffeine)
(Anhydrous simply means that all water has been removed to create a powdered form.)
 Caffeine Research Links:
Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers. (2002)
Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. (2005)
The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities. (2006)
Effect of caffeine ingestion on one-repetition maximum muscular strength. (2008)
Effect of caffeine on sport-specific endurance performance: a systematic review. (2009)
The effect of caffeine ingestion on mood state and bench press performance to failure. (2011)
Caffeine ingestion reverses the circadian rhythm effects on neuromuscular performance in highly resistance-trained men. (2012)

 

L-Norvaline

L-Norvaline can enhance and extend the vasodilation (a.k.a. pump) induced by Citrulline Malate by blocking the enzyme that normally limits Nitric Oxide production. When high blood concentrations of arginine produce NItric Oxide, they also cause the body produce the enzyme - arginase - that is used to break down and remove arginine, bringing levels back to normal. L-Norvaline will actually inhibit the arginase enzyme, preventing it from inhibiting your nitric oxide production.  In studies done at Texas A&M University, L-Norvaline has been shown to increase nitric oxide production by 55%! Again, higher Nitric Oxide levels result in increased blood flow to muscles - meaning prolonged pumps and vascularity during and after exercise. Typical effective dosage ranges from 150mg-250mg.
Norvaline Research Links:
Arginase modulates nitric oxide production in activated macrophages. (1998)
Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension. (2005)
Amino acids, arginase and nitric oxide in vascular health. (2006)

 

L-Theanine

Theanine is an amino acid, exclusively found in green tea, that has a unique and synergistic effect when combined with Caffeine. Theanine actually reduces the negative side effects of Caffeine, while enhancing the cognitive benefits such as alertness, focus, attention and mood. In addition, Theanine induces the production of nitric oxide, which further increases blood flow.
Theanine Research Links:
L-theanine, a natural constituent in tea, and its effect on mental state. (2008)
Psychological effects of dietary components of tea: caffeine and L-theanine. (2008)
The combined effects of L-theanine and caffeine on cognitive performance and mood. (2008)
The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. (2008)
The effects of L-theanine, caffeine and their combination on cognition and mood. (2008)
Arginase inhibitor in the pharmacological correction of endothelial dysfunction. (2011)

 

Alpha-GPC

Alpha GPC is an advanced form of Choline, and happens to be the most rapidly absorbed source of Choline available. Alpha-GPC works in the brain to increase levels of the neurotransmitter Acetylcholine, which is responsible for signaling muscle contraction. This means greater muscle fiber recruitment and more forceful muscle contraction. It is also the only form actually shown to increase power output in athletes after oral ingestion. 
Alpha-GPC Research Links:
The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students. (2010)
The effects of a multi-ingredient cognitive formula on alertness, focus, motivation, calmness and psychomotor performance in comparison to caffeine and placebo. (2014)
The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength. (2015)
The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. (2015)

 

Hordenine HCl

Hordenine is a naturally occurring alkaloid found in a variety of plants such as Barley. Hordenine acts as a Monoamin Oxidase Inhibitor (MAOI), meaning it blocks the enzyme (Monoamine Oxidase) responsible for the breakdown of Noradrenaline and can therefore enhance and even extend the effects of Caffeine. This ingredient is one of the main reasons why Amplified is able to increase and sustainenergy levels far beyond the capabilities of caffeine alone. 
(HCl stands for hydrochloride, which helps compounds easily dissolve into water)
 Hordenine Research Links:
Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. (1989)
Pharmacological effects of hordenine. (1995)
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